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A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer
Runjie Song, Peilan Guo, Xin Ren, Lijun Zhou, Peng Li, Nafis A Rahman, Sławomir Wołczyński, Xiru Li, Yanjun Zhang, Mei Liu, Jiali Liu & Xiangdong Li
PMID:37408008
Epub:2023 Jul 5
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Engineered hypermutation adapts cyanobacterial photosynthesis to combined high light and high temperature stress
Huili Sun, Guodong Luan, Yifan Ma, Wenjing Lou, Rongze Chen, Dandan Feng, Shanshan Zhang, Jiahui Sun & Xuefeng Lu
PMID:36871084
Epub:2023 Mar 4
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YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells
Peiqi Wang, Lingyi Huang, Fan Yang, Wanxi Chen, Ding Bai, Yongwen Guo
PMID:37197086
Epub:2023 May 14
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A novel salivary effector, BtE3, is essential for whitefly performance on host plants
Zhengke Peng, Qi Su, Jun Ren, Lixia Tian, Yang Zeng, Yuting Yang, Shaoli Wang, Wen Xie, Qingjun Wu, Zhenyu Li, Youjun Zhang
PMID:36648335
Epub:2023 Mar 28
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Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity
Yajun Zhou, Xing Lu, Xiaoqing Wang, Tianlei Ying, Xiangshi Tan
PMID:36835479
Epub:2023 Feb 17
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Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest
Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Li-Sha Zheng, Wei Dou, Yu Peng, Wen-Jie Bai, Zhen-Yu Li, John Vontas & Jin-Jun Wang
PMID:37667263
Epub:2023 Sep 5
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Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication
Xifeng Hu, Zheng Chen, Xiangdong Wu, Zhen Ding, Yu Huang, Qiuling Fu, Zhen Chen, Huansheng Wu
PMID:36602364
Epub:2023 Jan 31
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Flexible Amperometric Immunosensor Based on Colloidal Quantum Dots for Detecting the Myeloperoxidase (MPO) Systemic Inflammation Biomarker
Yanbing Tao,Yunong Zhao,Le Wang,Jing Huang,Yan Chen,Qing Huang,Boxiang Song,Hua-Yao Li,Jianjun Chen,Huan Liu
PMID:36832021
Epub:2023 Feb 10
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Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies
Mingtao Liu,Hui Gan, Zhiman Liang, Li Liu, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng, Baoqing Sun
PMID:37007494
Epub:2023 Mar 16
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The Additional 15 nt of 5′ UTR in a Novel Recombinant Isolate of Chilli Veinal Mottle Virus in Solanum nigrum L. Is Crucial for Infection
Q. Wan, Kaiyue Zheng, Jian Wu, Shan Bu, Mengting Jiao, Huijie Zhou, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Hairu Chen, Fei Yan, Jiejun Peng
PMID:37515116
Epub:2023 Jun 23
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Downregulation of lncRNA NEAT1 interacts with miR-374b-5p/PGAP1 axis to aggravate the development of osteoarthritis
Feiri Huang, Zhongliang Su, Jie Yang, Xizhen Zhao & Yaozeng Xu
PMID:37691099
Epub:2023 Sep 11
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CD163+ and CD14+ macrophages are increased in obese children
Nikita S. Denisov, Lyudmila V. Spirina, Iuliia G. Samoilova, Ekaterina M. Kamenskih, Ksenya A. Chubakova, Daria A. Sitnikova,Dmitry A. Svarovsky
PMID:37563845
Epub:2023 Aug 11
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Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies
Zixian Lu, Mei Yi, Taoli Chen, Yue He, Xia Fan, Hui Chen, Yinli Huang, Jianlou Niu, Xiaoqing Yan
PMID:37458432
Epub:2023 Jun 30
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DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
Yejinpeng Wang, Lingao Ju, Gang Wang, Kaiyu Qian, Wan Jin, Mingxing Li, Jingtian Yu, Yiliang Shi, Yongzhi Wang, Yi Zhang, Yu Xiao & Xinghuan Wang
PMID:37105989
Epub:2023 Apr 27
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Identification of an immunogenic epitope and protective antibody against the furin cleavage site of SARS-CoV-2
Lili Li, Meiling Gao, Jie Li, Xuping Xie, Hui Zhao, Yanan Wang, Xin Xu, Shulong Zu , Chunfeng Chen, Dingyi Wan, Jing Duan, Jingfeng Wang, Saba R. Aliyari, Sarah Gold, Jicai Zhang, Cheng-Feng Qin, Pei-Yong Shi, Heng Yang, Genhong Cheng
PMID:36508877
Epub:2023 Jan
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Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis
Ni Lian, Yujie Chen, Sihan Chen, Ying Zhang, Hao Chen, Yong Yang, Heng Gu, Qing Chen, Min Li & Xu Chen
PMID:37673869
Epub:2023 Sep 7
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UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer
Kanghua Xiao, Shengmeng Peng, Junlin Lu, Ting Zhou, Xuwei Hong, Siting Chen, Guangyao Liu, Hong Li, Jian Huang, Xu Chen, Tianxin Lin
PMID:37422473
Epub:2023 Jul 8
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Evaluation of the Immunological Efficacy of an LNP-mRNA Vaccine Prepared from Varicella Zoster Virus Glycoprotein gE with a Double-Mutated Carboxyl Terminus in Different Untranslated Regions in Mice
Yunfei Wang, Han Cao, Kangyang Lin, Jingping Hu, Ning Luan, Cunbao Liu
PMID:37766151
Epub:2023 Sep 11
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Development of an Antigen Detection Kit Capable of Discriminating the Omicron Mutants of SARS-CoV-2
Jiaji Li,Jinrong Shi,Zhijun Zhou,Bo Yang,Jiamin Cao,Zhongsen Cao,Qiang Zeng,Zheng Hu,Xiaoming Yang
PMID:36851181
Epub:2023 Jan 30
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Study of the Effects of Several SARS-CoV-2 Structural Proteins on Antiviral Immunity
Rong Yue, Fengyuan Zeng, Danjing Ma, Ziyan Meng, Xinghang Li, Zhenxiao Zhang, Haobo Zhang, Qi Li, Langxi Xu, Zhenye Niu, Dandan Li, Yun Liao, Guorun Jiang, Li Yu, Heng Zhao, Ying Zhang, Longding Liu, Qihan Li
PMID:36992107
Epub:2023 Feb 23
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A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice
Shimeng Bai, Tianhan Yang, Cuisong Zhu, Meiqi Feng, LiZhang, Ziling Zhang, Xiang Wang, Rui Yu, Xinghao Pan, Chen Zhao, Jianqing Xu, Xiaoyan Zhang
PMID:36761167
Epub:2023 Jan 17
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Pilot Study Results on Antibodies to the S- and N-Proteins of SARS-CoV-2 in Paired Sera from COVID-19 Patients with Varying Severity
Yulia Desheva, Anna Lerner, Tamara Shvedova, Olga Kopteva, Polina Kudar, Irina Koroleva, Galina Leontieva, Alexander Suvorov
PMID:36975366
Epub:2023 Feb 27
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Comparison of Immune Responses between Inactivated and mRNA SARS-CoV-2 Vaccines Used for a Booster Dose in Mice
Luan N, Cao H, Wang Y, Lin K, Hu J, Liu C
PMID:37376650
Epub:2023 Jun 11
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Insulin-like growth factor 1 promotes the gonadal development of Pampus argenteus by regulating energy metabolism
Yaya Li, Chang Li, Yangfei Fu, Ruixian Wang, Yang Yang, Man Zhang, Youyi Zhang, Xiangbing Wang, Guanlin Wang, Huan Jiang, Yushan Zou, Jiabao Hu, Chunyang Guo, Yajun Wang
PMID:37228017
Epub:2023 Aug 10
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Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin
A. V. Sokolov, I. N. Isakova-Sivak, D. A. Mezhenskaya, V. A. Kostevich, N. P. Gorbunov, A. Yu. Elizarova, V. A. Matyushenko, Yu. M. Berson, N. A. Grudinina, N. N. Kolmakov, Y. A. Zabrodskaya, A. S. Komlev, I. V. Semak, A. I. Budevich, L. G. Rudenko & V. B. Vasilyev
PMID:36334191
Epub:2023 Jun
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Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain
Qingqing Feng, Keman Cheng, Lizhuo Zhang, Xiaoyu Gao, Jie Liang, Guangna Liu, Nana Ma, Chen Xu, Ming Tang, Liting Chen, Xinwei Wang, Xuehui Ma, Jiajia Zou, Quanwei Shi, Pei Du, Qihui Wang, Guangjun Nie, Xiao Zhao
Epub:August 24, 2023
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FUS regulates the alternative splicing of cell proliferation genes related to atherosclerosis
Jianjun Hou, Shaobing Yang, Ying Guo, Ning Yan, Shaobin Jia
PMID:37688506
Epub:2023 Sep 9
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Comparison of the Immune Effects of an mRNA Vaccine and a Subunit Vaccine against Herpes Zoster Administered by Different Injection Methods
Kangyang Lin, Han Cao, Ning Luan, Yunfei Wang, Jingping Hu, Cunbao Liu
PMID:37243107
Epub:2023 May 20
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SARS-CoV-2 RBD Conjugated to Polyglucin, Spermidine, and dsRNA Elicits a Strong Immune Response in Mice
Ekaterina A Volosnikova, Iuliia A Merkuleva, Tatiana I Esina, Dmitry N Shcherbakov, Mariya B Borgoyakova, Anastasiya A Isaeva, Valentina S Nesmeyanova, Natalia V Volkova, Svetlana V Belenkaya, Anna V Zaykovskaya, Oleg V Pyankov, Ekaterina V Starostina, Alexey M Zadorozhny, Boris N Zaitsev, Larisa I Karpenko, Alexander A Ilyichev, Elena D Danilenko
PMID:37112720
Epub:2023 Apr 6
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Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
Yuxia Zhou, Lu Liu, Bangming Jin, Yixuan Wu, Lifen Xu, Xuebing Chang, Laying Hu, Guifang Wang, Yali Huang, Lingyu Song, Tian Zhang, Yuanyuan Wang, Ying Xiao, Fan Zhang, Mingjun Shi, Lingling Liu, Tuanlao Wang, Rui Yan, Bing Guo
PMID:36812572
Epub:2023 May 1
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Nasal immunization with AMH-INH-RFRP DNA vaccine for improving follicle development and fertility in buffaloes
Chao Chen, Xuhong Zhao, Zhigao An, Muhammad Jamil Ahmad, Kaifeng Niu, Xinxin Zhang, Pei Nie, Jiaomei Tang, Aixin Liang, Liguo Yang
PMID:36891049
Epub:2023 Feb 20
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Celastrol attenuates streptozotocin-induced diabetic cardiomyopathy in mice by inhibiting the ACE / Ang II / AGTR1 signaling pathway
Xuyong Zhao, Bingwu Huang, Jianhua Zhang, Wenjun Xiang, Ning Zhu
PMID:37700366
Epub:2023 Sep 12
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Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress
Yingchao Wu, Dajin Pi, Shuyao Zhou, Wuhong Wang, Huan Ye, Zhongjia Yi, Yiliu Chen, Mingzi Ouyang
PMID:37132527
Epub:2023 Jan-Dec
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Generation of a blockage monoclonal antibody of LILRB1 against HLA-G
Yunlong Shen, Ruirui Zhang, Xiaohua Jiang, Jinliang Yang
PMID:37683901
Epub:2023 Sep 6
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普健生物(AtaGenix)于2012年在武汉成立,作为武汉国家生物产业基地公共服务平台——光谷抗体发现与筛选公共服务平台,普健生物(AtaGenix)专注于重组蛋白、抗体、诊断原料、抗体药物发现等自主技术平台的建设和下游生物医药产品的战略合作。经过10年的发展,普健生物已成为一家立足武汉,业务覆盖全国、辐射全球的高新技术服务企业。目前公司拥有4700平米自建实验室(包含800平高标准BSL-2级细胞房),拥有齐全蛋白抗体开发设备500余套,包括高通量蛋白纯化仪、Agilent 流式细胞分析仪,全自动HPLC分析仪,openSPR蛋白、抗体亲和力测定仪,Olympus荧光显微镜, BTX电融合仪,2*7L微生物发酵罐,中试型高压均质机,全自动管式化学发光仪,以及配套的高速离心机,细胞计数仪及大容量细胞培养摇床。公司先后获得荣誉:3551人才计划、高新技术企业、技术先进型服务企业、光谷瞪羚企业。